T.S. Sych defended his PhD thesis at St. Petersburg University (St. Petersburg). Dissertation topic: "Luminescent noble metal clusters stabilized by protein matrices: photophysical and structural properties, practical applications". The current research interests include noble metal nanoobjects (clusters and nanoparticles) stabilized by biopolymer matrices. The main results include: 1) synthesis of silver clusters on the tRNA matrix; 2) development of techniques for determination of albumin and immunoglobulin in blood serum using silver and gold clusters; 3) development of techniques for selective determination of dioxyphenylalanine in blood serum samples using silver nanoparticles.

The main research areas are at the intersection of physics, chemistry, medicine and biology and are associated with the development and study of the structure of various supramolecular complexes based on polymers and biopolymers:

• Metal clusters (silver, gold) stabilized by biopolymer matrices (DNA, proteins, amino acids)
• Biosensors based on DNA and protein complexes with metal clusters for medical diagnostics
• Photonics of biomolecules

Main research methods:

• stationary and time spectroscopy
• mass spectrometry and XPS

Main grants in recent years:

• "Hybrid structures based on fluorescent nanoclusters of metals, DNA, and graphene" (SPbU)
• "Mechanisms of Self-Assembly of Supramolecular Structures Based on Chromatin Architech Proteins" (RFBR)
• “Korean-Russian international cooperation on the creation of new hybrid nanomaterials for biosensorics and photodynamic therapy” (RFBR)
• "A new approach to visualization of tRNA in vitro using fluorescent metal clusters" (RFBR, head of the project)
• "Luminescent metal nanoclusters in nucleoprotein matrices" (RSF)
• "Development and characterization of biosensor systems based on metal nanoclusters for the detection of biomarkers and phototherapy of vitiligo" (RSF)

Publications of recent years in the most rated journals:

1. Volkov I., Sych T., Serdobintsev P., et al. Fluorescence saturation spectroscopy in probing electronically excited states of silver nanoclusters. Journal of Luminescence, 2016, 172:175-179. https://doi.org/10.1016/j.jlumin.2015.12.019
2. Vdovichev A.A., Sych T.S., Reveguk Z.V., et al. Structure of fluorescent metal clusters on a DNA template. Journal of Physics: Conference Series, 2016, 741(1):012069. http://dx.doi.org/10.1088/1742-6596/741/1/012069
3. Ramazanov R.R., Sych T.S., Reveguk Z.V., et al. Ag-DNA emitter: metal nanorod or supramolecular complex? Journal of Physical Chemistry Letters, 2016, 7(18), 3560-3566. http://dx.doi.org/10.1021/acs.jpclett.6b01672
4. Sych T., Polyanichko A., Kononov A. Albumin-stabilized fluorescent silver nanodots. Journal of Molecular Structure, 2016, 1140, 19-21. http://dx.doi.org/10.1016/j.molstruc.2016.09.088
5. Sych T.S., Buglak A.A., Reveguk Z.V., et al. Which amino acids are capable to nucleating fluorescent silver clusters in proteins? The Journal of Physical Chemistry C, 2018, 122(45), 26275-26280. http://dx.doi.org/10.1021/acs.jpcc.8b08979
6. Sych T.S., Reveguk Z.V., Pomogaev V.A., et al. Fluorescent silver clusters on protein template: understanding their structure. The Journal of Physical Chemistry C, 2018, 122(51), 29549-29558.  http://dx.doi.org/10.1021/acs.jpcc.8b08306
7. Sych T.S., Polyanichko A.M., Ramazanov R.R., Kononov A.I. tRNA as stabilizing matrix for fluorescent silver clusters: photophysical properties and IR study. Nanoscale Advances, 2019, 1, 3579-3583. http://dx.doi.org/10.1039/C9NA00112C
8.  Sych T.S., Polyanichko A.M., Plotnikova L.V., Kononov A.I. Luminescent silver nanoclusters in probing immunoglobulins and serum albumins in protein mixtures. Analytical Methods, 2019, 11(48), 6153-6158.  http://dx.doi.org/10.1039/C9AY02054C
9. Mizincev A.V., Sych T.S., Polyanichko A.M., et al. Fluorescent Ag-nanoclusters for evaluation of serum albumin and immunoglobulin content in protein mixtures. Journal of Physics: Conference Series, 2020, 1695(1):012061. http://dx.doi.org/10.1088/1742-6596/1695/1/012061
10. Sych T.S., Polyanichko A.M., Buglak A.A., Kononov A.I. Quantitative determination of albumin and immunoglobulin in human serum using gold nanoclusters. Spectrochimica Acta Part A, 2023, 298:122796. https://doi.org/10.1016/j.saa.2023.122796
11. Reveguk Z.V., Sych T.S., Polyanichko A.M., et al. Rapid and selective colorimetric determination of L-DOPA in human serum with silver nanoparticles. Spectrochimica Acta Part A, 2023, 299:122810. http://dx.doi.org/10.1016/j.saa.2023.122810